The Effect of Panaxadiol Saponins(PDS) on Antioxidation and Neuroendocrine Factor in Ventricular Remodeling Rats

Objective To study the effect of Panaxadiol Saponins(PDS) on Antioxidation and neuroendocrine factor in ventricular remodeling rats.Methods The ventricular remodeling model was induced by myocardial infarction in rats of left anterior descending coronary occulusion.The wistar rats were divided into 4 groups,including sham operation group,remodeling model group,PDS group,andCaptopril group.The rats in sham operation group and remodeling model group were treated with normal sodium(with 2 ml·kg-1·d-1 i.p).The PDS group was treated PDS(with 50 mg·kg-1·d-1 i.p).The Captopril group was treated Captopril(with 100 mg·kg-1·d-1 i.g).After 4 weeks,The content of endothelin(ET)、antrial natriuretic peptide(ANP)、aldosterone(ALD)、angiotensin Ⅱ(AngⅡ) in plasma were determined.The content of malondialdehyde(MDA) in serum and myocardial AngⅡ,the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in serum were also determined.Results The content of ET、ANP、ALD、AngⅡ in plasma were declined.In addition,the content of MDA in serum and myocardial AngⅡ were also declined,then the activities of SOD and GSH-Px in serum were increased markedly.Conclusion PDS has protective effects on ventricular remodeling through inhibitting renin-angiotensin-aldosterone system to reduce contractive materials and reinforcing ability of antioxidation.