STUDY ON PREVENTION OF POSTPARTUM HEMORRHAGE OF CESAREAN SECTION WITH OXYTOCIN AND CARBOPROST IN HIGH RISK PREGNANT WOMEN

[Objective]To observe the effect and safety of oxytocin and carboprost on prevention of postpartum hemorrhage during cesarean section and after cesarean section in high risk pregnant women.[Methods]Oxytocin,carboprost and oxytocin plus carboprost were used in cesarean section for 123 pregnant women with high risk factor as hemorrhage,the amount of bleeding during the operation and within 2-hour after delivery were measured and the side effect of each group was observed.[Results]The amount of bleeding during cesarean section in oxytocin group(O)was(625 ± 315)ml,in carboprost group(C)was(489 ± 289)ml,and in oxytocin plus carboprost group(O+C)was(439±225)ml. There was a significant difference between groups O and C(P﹤0.05). There was an extremely significant difference between groups O and O+C(P﹤0.05). There was no significant difference between groups H and O+C(P﹥0.05). The incidence of side effects in the three groups was 4.9%,8.9% and 4.9%,respectively. Vomiting was frequently seen in the three groups but recovered soon without treatment.[Conclusion]Carboprost can reduce the amount of bleeding during the cesarean section in pregnant women with high risk factor as hemorrhage significantly and can be used with oxytocin to obtain better effects in preventing hemorrhage during and after delivery.