Observation on Curative Effect of Carboprost Combined with Oxytocin on Prevention of High-risk Maternal Postpartum Hemorrhage

Objective To observe the therapeutic efficacy of carboprost and oxytocin on prevention of high-risk maternal postplartum hemorrhage after cesarean section. Methods We selected 200 high-risk parturient women who took in the caesarean birth in the People's Hospital of Yongqing County from January 2008 to December 2010.They were randomly divided into research group and control group(each n=100).The women in research group were given 1 mg of carboprost and 20 U of oxytocin.The women in control group were only received 20 U of oxytocin after fetal childbirth.The intraoperative bleeding,blood loss during the first 2 postoperative hours,and the total bleeding volume were observed. Results The intraoperative bleeding of 100 cases of research group was(302±178) ml,blood loss during the first 2 postoperative hours was(108±78) ml,and the total bleeding volume was(408±207) ml.The intraoperative bleeding of 100 cases of control group was(428±206) ml,blood loss during the first 2 postoperative hours was(141±92) ml,and the total bleeding volume was(558±285) ml.There were statistically significant difference between the two groups(P0.05).There were 3 patients(3%) in research group and 6 patients(6%) in control group whose total bleeding volume was ≥ 1,000 ml. Conclusions Carboprost combined with oxytocin can effectively prevent high-risk maternal bleeding after cesarean section,and its function is superior to oxytocin used alone.It is worthy of clinical promotion.