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2012•Shandong yiyaoRequires access

Expression and correlation of Per 2 and PCNA in glioma

Hechun Xia

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Abstract

Objective To investigate the expression and correlation of Per 2 and PCNA in glioma,and the relationship in Per 2 and PCNA with clinicopathologic features.Method The expression of Per 2 and PCNA in 37 cases of gliomas and nontumor tissues was detected by immunohistochemical ABC method.Results The positive rate of Per 2 was lower,and PCNA was higher in glioma tissue than that in nontumor one(all P0.05).There was a negative correlation between the expression of Per 2 and PCNA in gliomas(r=-0.492,P0.05).Conclusions The Per 2 is lowely and the PCNA is higherly expressed in glioma tissue,and there is a negative correlation.The expression of Per 2 and PCNA may be a mechanism in occurrence and progression of gliomas.

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Objective To investigate the expression and correlation of Per 2 and PCNA in glioma,and the relationship in Per 2 and PCNA with clinicopathologic features.Method The expression of Per 2 and PCNA in 37 cases of gliomas and nontumor tissues was detected by immunohistochemical ABC method.Results The positive rate of Per 2 was lower,and PCNA was higher in glioma tissue than that in nontumor one(all P0.05).There was a negative correlation between the expression of Per 2 and PCNA in gliomas(r=-0.492,P0.05).Conclusions The Per 2 is lowely and the PCNA is higherly expressed in glioma tissue,and there is a negative correlation.The expression of Per 2 and PCNA may be a mechanism in occurrence and progression of gliomas.

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Available abstract

Objective To investigate the expression and correlation of Per 2 and PCNA in glioma,and the relationship in Per 2 and PCNA with clinicopathologic features.Method The expression of Per 2 and PCNA in 37 cases of gliomas and nontumor tissues was detected by immunohistochemical ABC method.Results The positive rate of Per 2 was lower,and PCNA was higher in glioma tissue than that in nontumor one(all P0.05).There was a negative correlation between the expression of Per 2 and PCNA in gliomas(r=-0.492,P0.05).Conclusions The Per 2 is lowely and the PCNA is higherly expressed in glioma tissue,and there is a negative correlation.The expression of Per 2 and PCNA may be a mechanism in occurrence and progression of gliomas.

Key concepts: Proliferating cell nuclear antigen, Glioma, Immunohistochemistry, Correlation, Positive correlation, Biology, Cancer research, Pathology

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Expression and correlation of Per 2 and PCNA in glioma — Research Paper | ScholarLens