Correlation Between Expression of MDR1/P-gp Gene and CerbB-2,p53 Genes and its Clinical Significance in Breast Cancer

Objective To investigate the correlation between expression of MDR1/P-gp gene and CerbB-2,p53 genes and its clinical significance in breast cancer.Methods SP immunohistochemical method was used to detect the expression of MDR1/P-gp gene and CerbB-2,p53 genes in breast cancer.Results The positive rates of expression of MDR1/P-gp,CerbB-2,and p53 were 41.4%,51.1% and 38.7 %,respectively.The overexpression rate of CerbB-2 was significantly higher in the group with expression of P-gp(37.66%)than that in the group with non-expression of P-gp(20.18%).The overexpression rate of p53 was also higher in the group with expression of P-gp(28.57%)than that in the group with non-expression of P-gp(15.60%).The expression of P-gp was not correlated with tumor diameter,lymph node metastasis,clinical stages,pathological types and the receptors for estrogen and progestogen(P0.05).The positive rate of CerbB-2 and p53 expression was significantly increased in axillary lymph node positive breast cancer.Conclusions MDR1/P-gp,CerbB-2 and p53 are co-expressed in breast cancer and have a relationship with multidrug resistance.Combined detection might be useful in the establishment of synthetic therapy regimen in breast cancer.