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2001•Acta Academiae Medicinae JiangxiRequires access

Low-dose Cyclosporin A in the Treatment of Chronic Aplastic Anemia

Qingzhi Shi

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Abstract

Objectives: To explore the clinical effect of low-dose cyclosporin A (CSA) on chronic aplastic anemia (CAA) and the factor for predicting. Methods: a randomized control trial was employed to determine whether the outcome of CAA treated with low-dose CSA was better than that with routine drugs. Results: the effective rate in half a year and one year of low-dose CSA group (75%, 79.2%) was significantly higher than that of routine drugs (23.8%, 38.1%). The outcome was related to T lymphocyte subset and the results of CSA testing in vitro. Conclusions: The effective rate of low-dose CSA was better than that of routine drugs for CAA. The CSA testing in vitro could be used to predict the effects of CSA on some patients with CAA.

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What this paper is about

Objectives: To explore the clinical effect of low-dose cyclosporin A (CSA) on chronic aplastic anemia (CAA) and the factor for predicting. Methods: a randomized control trial was employed to determine whether the outcome of CAA treated with low-dose CSA was better than that with routine drugs. Results: the effective rate in half a year and one year of low-dose CSA group (75%, 79.2%) was significantly higher than that of routine drugs (23.8%, 38.1%). The outcome was related to T lymphocyte subset and the results of CSA testing in vitro. Conclusions: The effective rate of low-dose CSA was better than that of routine drugs for CAA. The CSA testing in vitro could be used to predict the effects of CSA on some patients with CAA.

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Available abstract

Objectives: To explore the clinical effect of low-dose cyclosporin A (CSA) on chronic aplastic anemia (CAA) and the factor for predicting. Methods: a randomized control trial was employed to determine whether the outcome of CAA treated with low-dose CSA was better than that with routine drugs. Results: the effective rate in half a year and one year of low-dose CSA group (75%, 79.2%) was significantly higher than that of routine drugs (23.8%, 38.1%). The outcome was related to T lymphocyte subset and the results of CSA testing in vitro. Conclusions: The effective rate of low-dose CSA was better than that of routine drugs for CAA. The CSA testing in vitro could be used to predict the effects of CSA on some patients with CAA.

Key concepts: Medicine, Aplastic anemia, Internal medicine, Randomized controlled trial, Clinical trial, Gastroenterology, Bone marrow

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