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2014•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Advances in understanding the role of TGF-β/Smad signalling pathways in the pathogenesis of liver fibrosis

FU Ling-zh

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Abstract

Liver fibrosis is the common pathway of virtually various chronic liver diseases to the liver cirrhosis,which is characterized by the excessive accumulation of collagen-based extracellular matrix for imbalance between synthesis and degradation.It is regulated by multiple cell signaling pathways and a series of cellular molecular information networks. Transforming growth factor-β(TGF-β)is one of the strongest profibrotic cytokines,and TGF-β/Smad signaling pathway is the main way of various types of TGF-βsignal.It activates hepatic stellate cell(HSC)to promote ECM production.This review is related to the effect of TGF-β/Smad signaling pathway in the progress of liver fibrosis.

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What this paper is about

Liver fibrosis is the common pathway of virtually various chronic liver diseases to the liver cirrhosis,which is characterized by the excessive accumulation of collagen-based extracellular matrix for imbalance between synthesis and degradation.It is regulated by multiple cell signaling pathways and a series of cellular molecular information networks. Transforming growth factor-β(TGF-β)is one of the strongest profibrotic cytokines,and TGF-β/Smad signaling pathway is the main way of various types of TGF-βsignal.It activates hepatic stellate cell(HSC)to promote ECM production.This review is related to the effect of TGF-β/Smad signaling pathway in the progress of liver fibrosis.

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Available abstract

Liver fibrosis is the common pathway of virtually various chronic liver diseases to the liver cirrhosis,which is characterized by the excessive accumulation of collagen-based extracellular matrix for imbalance between synthesis and degradation.It is regulated by multiple cell signaling pathways and a series of cellular molecular information networks. Transforming growth factor-β(TGF-β)is one of the strongest profibrotic cytokines,and TGF-β/Smad signaling pathway is the main way of various types of TGF-βsignal.It activates hepatic stellate cell(HSC)to promote ECM production.This review is related to the effect of TGF-β/Smad signaling pathway in the progress of liver fibrosis.

Key concepts: SMAD, Signal transduction, Hepatic stellate cell, Extracellular matrix, Transforming growth factor, Fibrosis, Cirrhosis, Cell biology

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