2007•International Journal of Digestive DiseasesRequires access

Smad7 and liver fibrosis

Haili Liu

Abstract

Transforming growth factor-β1(TGF-β1) plays a great role in the process of liver fibrosis. Smad protein family are important molecules in TGF-β signaling. Among them,Smad7 can block liver fibrosis mediated by TGF-β through inhibiting TGF-β signal transduction pathway and mediating intracellular negative feedback. This review will briefly introduce the mechanisms of Smad7 inhibiting liver fibrosis.

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Available abstract

Key concepts: SMAD, Liver fibrosis, Transforming growth factor, Signal transduction, Fibrosis, Intracellular, Hepatic fibrosis, Cell biology