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Transforming Growth Factor-β Pathway and Molecular Treatment of Liver Fibrosis

LU Lunge

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Abstract

Many research studies have demonstrated that hepatic stellate cells (HSC) play a key role in fibrogenesis. Transforming growth factor-β (TGF-β) activates HSC and enhances the synthesis and deposition of extracellular matrix (ECM) in the liver. TGF-β-Smad signal pathway is the main pathway for TGF-β to exert its biological effects. The molecular constituents and modulation of this pathway are complicated, and have mutual influence with other signal pathways. Further study of TGF-β-Smad signal pathway not only enables the explanation for the pathogenesis of liver fibrosis, but also provides effective avenue for its prevention and treatment.

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What this paper is about

Many research studies have demonstrated that hepatic stellate cells (HSC) play a key role in fibrogenesis. Transforming growth factor-β (TGF-β) activates HSC and enhances the synthesis and deposition of extracellular matrix (ECM) in the liver. TGF-β-Smad signal pathway is the main pathway for TGF-β to exert its biological effects. The molecular constituents and modulation of this pathway are complicated, and have mutual influence with other signal pathways. Further study of TGF-β-Smad signal pathway not only enables the explanation for the pathogenesis of liver fibrosis, but also provides effective avenue for its prevention and treatment.

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Available abstract

Many research studies have demonstrated that hepatic stellate cells (HSC) play a key role in fibrogenesis. Transforming growth factor-β (TGF-β) activates HSC and enhances the synthesis and deposition of extracellular matrix (ECM) in the liver. TGF-β-Smad signal pathway is the main pathway for TGF-β to exert its biological effects. The molecular constituents and modulation of this pathway are complicated, and have mutual influence with other signal pathways. Further study of TGF-β-Smad signal pathway not only enables the explanation for the pathogenesis of liver fibrosis, but also provides effective avenue for its prevention and treatment.

Key concepts: SMAD, Transforming growth factor, Extracellular matrix, Signal transduction, Hepatic stellate cell, Cell biology, Pathogenesis, Liver fibrosis

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