The Clinical Analysis of Pregnancy Outcome of 411 Cases of Preterm Premature Rupture of Membrane

Objective: To understand the impact of preterm premature rupture of membrane(PPROM) of different gestational age and antenatal treatment with corticosteroid on the neonatal outcome.Methods:The clinical data of 411 cases of preterm premature rupture of membrane were analyzed retrospectively,and neonatal outcome were compared between different gestational age and antenatal treatment with corticosteroid.Results:The neonatal birth weight,RDS,asphyxia and death in the group less than 34 gestation age was significantly higher than in the group of 34+1~36+6 gestational age(P0.001).The incidence of sever asphyxia,RDS and death in the treatment group was significantly lower than in the control group of 32~34 gestational age(P0.05).All index about the neonatal outcome in the treatment group had no significant difference with control group between 28~31+6 and 34+1~36+6 gestational age(P0.05).Conclusion:In patients with PPROM with a gestational age less than 34,a waiting management scheme is advised to prolong gestational age and decrease neonatal morbidity,antenatal treatment with corticosteroid could improve the neonatal outcome of PPROM with 32~34 gestational age.