The Clinical Analysis of the Neonatal Outcome of 286 Cases of Preterm Premature Rupture of the Membranes

Objective:To understand the impact of antenatal treatment with corticosteroid on the neonatal outcome of preterm premature rupture of the membranes.Methods:The clinical data of 286 cases of preterm labor with PROM were analyzed retrospectively.Among them,199 cases with different gestational age were treated by Dexamethasone before labor as treatment group,and other 87 cases as control group without any antenatal treatment.Results: The incidence of neonatal Apgar score in one minute7,asphyxia and NRDS in the treatment group was significantly lower than in the control group in 34-35~(+6) gestational age(P0.05).The incidence of neonatal asphyxia、HIE,NRDS and other complications in the treatment group was significantly lower than in the control group in 36～36~(+6) gestational age(P0.05).All index about the neonatal outcome had no significant difference between 28～31~(+6) and 32～33~(+6) gestational age(P0.05).Conclusions: Antenatal treatment with corticosteroid could improve the neonatal outcome of premature rupture of the membranes within 34～36~(+6) gestational ages.However, its effect on preterm neonatal of gestational week less than 34 is uncertain because of the limited number of cases.