2013•Applied Chemical IndustryRequires access
One-pot synthesis of isoamyl p-methoxycinnamate
Huijun Li
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Abstract
Isoamyl p-methoxycinnamate was synthesized by knoevenagel condensation from p-methoxybenzaldehyde and diethyl malonate with the catalysis of glycine in isoamyl alcohol.The effects of molar ratio of reactants,reaction temperature,reaction time and dosage of catalyst on the product yield were investigated.The experiment showed that when n(diethyl malomate) ∶ n(p-methoxybenzaldehyde) ∶ n(glycine) = 1.6 ∶ 1.0 ∶ 0.25,reaction temperature 120 ℃,and reaction time 8 h,the yield of isoamyl p-methoxycinnamate was up to 85.8%.