Comparison of PCIA effect of nefopam and tramadol on postanorectal operation pain

Objective To compare the patient controlled intravenous analgesic effect of nefopam and tramadol on postanorectal pain.Methods Sixty patients,ASAⅠ～Ⅱscheduled caudal block for anorectal surgery,were randomly divided into two groups:Group N (nefopam group,nefopam 160 mg+gran- isetron 3 mg)30 cases,group T(tramadol group,tramadol 800 mg+granisetron 3 mg)30 cases.0.5% ropivacaine was used in caudal block.At the end of operation the background infusion of PCA pump was 2 ml/h,a bolus 0.5 ml with 20 minute lock-out.The pain relief of patients in 48 hours,using visual analogue scale (VAS)to assess the analgesic effect of the two groups,were compared.Results The VAS in group N and T patients were significantly reduce postoperatively(VAS3),and the side effects in group N patients were significantly less than that in group T.Conclusion The analgesic effect of nafopam is similar to tramadol after anorectal operation,but with less side effects.