Effects of Concurrent Administration of Azastron on the analgesic of PCIA with Tramadol

Objective:To evaluate the analgesic effects of tramadol in surgical patients receiving patient-controlled intravenous analgesia(PCIA)with concurrent administration of azastron.Methods:Ninty patients(ASAⅠ~Ⅱ)undergoing selective upper abdominal surgery were randomly divided into three groups with 30 cases each.Group A was given azasetron 10mg,tramadol 1500 mg and 0.9%NaCl diluted to 100ml,group B metoclopramide 20 mg,tramadol 1500 mg and 0.9%NaCl diluted to 100ml,and group C tramadol 1500 mg plus 0.9%NaCl diluted to 100ml,and group C tramadol 1500mg plus 0.9%NaCl diluted to 100ml.Postoperative pain nausea and vomiting,sedation,other side effects and the dosage of tramadol were observed at 4,8,12 and 24h during postoperative analgesia.Results:The VAS scores in group A were higher than those in group C and group B at 4h and 8h after operation(P0.05).Meanwhile,the accumulative total amount of tramadol in group A was more than that in group C and group B at 8,12 and 24h after operation(P0.05).The incidence of nausea and vomiting in group A was obviously lower than that in group C and group B postoperatively(P0.01,P0.05).Sedation scores were similar among three groups.Conclusion:Azasetron can inhibit the analgesic effects of tramadol during PCIA.