Clinical Observation of Postoperative Intravenous Analgesia with Nefopam

Objective To assess the analgesic and side effects of postoperative intravenous analgesia with nefopam as compared with tramadol. Methods Sixty grade Ⅰ～Ⅱ ASA patients undergoing elective operation were randomly divided into two groups: group N ( n =30) received postoperative intravenous analgesia with nefopam, and group T( n =30) received postoperative intravenous analgesia with tramadol. In group N, nefopam 120mg and Granisetron 3mg were diluted with normal saline to 100ml, while in group T tramadol 800mg and Granisetron 3mg were diluted with normal saline to 100ml. The patients received a loading dose (group N: nefopam 20mg iv; group T: tramadol 100mg iv) before suturing skin and then received the analgesia pump. Pain score (VAS 0～10), sedation score(0～3) and side effects were recorded at 4?8?12?24 and 48h after operation. Results There was no significant difference in pain and sedation scores between the two groups ( P 0.05). The incidence of side effects in tramadol group was higher than that in nefopam group ( P 0.05). Conclusion Nefopam is safe and effective in the treatment of postoperative pain, and has less side effect.[