Clinical curative effect comparison of different kinds of glucocorticoid treated with AECOPD

Objective To study on clinical curative effect and its differences of different kinds of glucocorticoid treated with AECOPD.Methods 170 patients with AECOPD were randomly divided into 5 groups.Prednisone group was given prednisone(30-40 mg/d) by oral medication.Hydrocortisone,methylprednisolone and dexamethasone groups were injected hydrocortisone(20 mg/d),methylprednisolone(40 mg/d) and dexamethasone(5 mg/d) by intravenous drip,respectively.Each group was administered for 7 days.Normal therapy was conducted in the control group.The symptoms disappear time,the rate total effective and adverse reactions were counted and compared.Results Compared with the C-G group,the glucocorticoid treatment group total effective rate were significantly higher than that of the C-G group.Methylprednisolone had higher efficient,lower incidence of adverse reactions and shorter eliminate time of symptoms.It's efficient and incidence of adverse reactions were 91.17% and 14.71%,respectively.Conclusion In the glucocorticoid,methylprednisolone is the most appropriate choice for the treatment of AECOPD.