Clinical comparison on shock treatment with methylprednisolone and dexamethasone in children with acute primary idiopathic thrombocytopenic purpura

Objective To compare the clinical effect and adverse reactions of shock treatment with methylprednisolone and dexamethasone in children with acute primary idiopathic thrombocytopenic purpura(ITP).Methods We retrospectively reviewed a cohort of 78 children with acute primary ITP.The patients were divided into two groups,methylprednisolone group(n=44)and dexamethasone group(n=34).Patients in methylprednisolone group were given 20 — 30 mg/(kg·d)methylprednisolone for 3 d,and patients in dexamethasone group were given 1.5 — 2 mg/(kg·d)dexamethasone for 3 d.The amounts of drugs in two groups were reduced from the day 4.On the day 7,patients were po received Asaison 1.6 mg/(kg·d)to carry out sequential therapy.We observed the platelet counts and the responses to treatments in two groups,respectively.The platelet numbers of the two groups were detected and the average reaction time was calculated since the beginning of therapy to be completely effective or effective and bleeding stopped time.At the same time,the adverse reactions of the patients were observed during the treatment.Results There was no significant difference in the treatment efficiency and bleeding stopped time between two groups(P0.05).No patients experienced severe adverse reaction.There was no significant difference in the adverse reactions between two groups(P0.05).Conclusion Two kinds of glucocorticoid are equally effective in curing acute primary ITP,and the short-term adverse reactions are mild.