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Advance in Studies on Glucagon-like Peptide-2

Xiulan Guo

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Abstract

GLP-2 is a 33-amino acid peptide secreted from L cells of the small intestine. GLP-2 plays a key role in the development of gastrointestinal-tract of neonatal animal. GLP-2 regulates gastric motility, gastric acid secretion, intestinal hexose transport, and increases the barrier function of the gut epithelium. The actions of GLP-2 are transduced by the GLP-2 receptor, a G protein-coupled receptor. These make GLP-2 become an important hormone in physiology. The structure, physiological effect, mechanism of action, secretion and degradation of GLP-2 were summarized in the article.

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What this paper is about

GLP-2 is a 33-amino acid peptide secreted from L cells of the small intestine. GLP-2 plays a key role in the development of gastrointestinal-tract of neonatal animal. GLP-2 regulates gastric motility, gastric acid secretion, intestinal hexose transport, and increases the barrier function of the gut epithelium. The actions of GLP-2 are transduced by the GLP-2 receptor, a G protein-coupled receptor. These make GLP-2 become an important hormone in physiology. The structure, physiological effect, mechanism of action, secretion and degradation of GLP-2 were summarized in the article.

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Available abstract

GLP-2 is a 33-amino acid peptide secreted from L cells of the small intestine. GLP-2 plays a key role in the development of gastrointestinal-tract of neonatal animal. GLP-2 regulates gastric motility, gastric acid secretion, intestinal hexose transport, and increases the barrier function of the gut epithelium. The actions of GLP-2 are transduced by the GLP-2 receptor, a G protein-coupled receptor. These make GLP-2 become an important hormone in physiology. The structure, physiological effect, mechanism of action, secretion and degradation of GLP-2 were summarized in the article.

Key concepts: Secretion, Motility, Hexose, Gastrointestinal tract, Receptor, Gastric acid, Glucagon-like peptide-2, Biology

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