Clinical value of loop electrosurgical excision procedure in diagnosis and treatment of cervical intraepithelial neoplasia:a follow-up

Objective To assess the clinical value of loop electrosurgical excision procedure(LEEP) in the diagnosis and treatment of patients with cervical intraepithelial neoplasia(CIN).Methods Totally 139 CIN patients(confirmed with pathological diagnosis) who were voluntarily treated by LEEP were followed-up for 3 months,6 months and 2 years after LEEP.The consistent rates between the results of thinPrep cytologic test(TCT),colposcopy biopsy,and the pathological diagnosis after LEEP were analyzed.The residual lesions after LEEP and recurrent rate were observed.Results The consistent rate of the results of multiple punch biopsy and pathological diagnosis after LEEP was 85.6%.The overall cure rate during the 2-year-follow-up was 95.7%.The residual CIN was found in 1.4% patients,but none occurred within the first 6 months after LEEP.During the 2 years follow-up,the overall cure rates were 99.0% and 88.1% in CIN Ⅰ and CIN Ⅱ—Ⅲ groups,respectively.The residual rates were 1.0% and 2.4%,and the recurrent rates were 0 and 9.5% in CIN Ⅰ and CIN Ⅱ—Ⅲ groups,respectively.In the recurrent patients 3 had HPV16 infection,2 had HPV16 and 18 infection,and one had HPV53 infection.Conclusion LEEP is a reliable,safe and effective method for diagnosis of CIN and cervical carcinoma in situ,and long-term follow-up is necessary for the patients after LEEP.(Shanghai Med J,2009,32: 903-905)