Lipid peroxidation injury of liver after ischemia-reperfusionand protection effect of vitamin C

Aim To explore the treating effect of vitamin C(Vit C) on lipid peroxidation injury of liver after ischemiz-reperfusion.Methods A model of hepatic ischemia-reperfusion in rabbits was established to investigate the alterations of lipid peroxide by measuring malondialdehyde (MDA) and vitamin E (Vit E) in plasma or liver tissue, and to observe the morphologica changes of hepatocytes.A large dose of VitC was given to the model aninals to observe its preventing and treating effects on lipid peroxidation injury of the liver (VitC in a dose of 0.25 g·kg-1).Results The degree of lipid peroxidation was strengthened and the morphological changes of hepatocytes were more obvious during hepatic ischemia -reperfusion when Vit C was given before ischemia and before reperfusion, respectively, the degree of lipid peroxidation was remarkabley weakened and the abnormal changes of hepatocytes were significantly attenuated.Conclusion Vit C in a dose of 0.25 g·kg-1 would inhibit or ameliorate lipid peroxidation injury of liver after ischemia-reperfusion.