1991•上海交通大学学报：医学英文版Requires access
EFFECT OF ALCOHOL ON HEPATIC LIPID PEROXIDATION
张佩瑾, 孙琛, 俞霭瑶
Open publisher page 0 citations
Abstract
The present study investigated the change of hepatic lipid peroxidation after ethanol adiministration, the protection of Vit E, and discussion on its toxicological mechanism. The level of lipid peroxidation in mitochondria was risen around 50% and no change of lipid peroxidation in homogenate occurred. However no significant difference of superoxide dismutase (SOD) activity was observed. Vit E could inhibit the production of malondialdehyde (MDA) but had no antagonistic effect on ethanol action. For above reasons, we concluded that lipid peroxidation did not initiate the cell injury until sequence of cell damage.