2015•PubMedRequires access

[THE INFLUENCE OF CARBON MONOXIDE ON THE PARAMETERS OF PROOXIDANT-ANTIOXIDANT BALANCE DURING HEPATIC ISCHEMIA-REPERFUSION SYNDROME IN RATS].

M. N. Khodosovsky, В. В. Зинчук, I. E. Gulyai

Abstract

The influence of carbon monoxide on the blood and liver prooxidant-antioxidant parameters: lipid peroxidation products (conjugated dienes, malondialdehyde, Schiff bases) and antioxidant system parameters (catalase, retinol, α-tocopherol, glutathione) were investigated in rats during hepatic ischemia-reperfusion. Hepatic ischemia was induced by Pringle maneuver for 30 min, reperfusion period was 120 min. It is detected, that hepatic ischemia-reperfusion leads to intensification of lipid peroxidation with declining of antioxidant defense. Infusion of the donor CO before reperfusion period improves the prooxidant-antioxidant balance in the blood and liver. In conclusion, CO increases the antioxidant activity of the blood and liver, decreases lipid peroxidation processes, that's correct oxidative damages during hepatic ischemia-reperfusion.

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Key concepts: Lipid peroxidation, Antioxidant, Chemistry, Malondialdehyde, Ischemia, Reperfusion injury, Oxidative stress, Glutathione