Expression and significance of NF-κB and PKCβII receptor in gastric carcinoma

Objective To detect the expression of NF-κB and PKCβⅡin gastric carcinoma,discuss their correlation in gastric carcinoma tissues and the relationship with clinicopathological parameters.Methods The expression of NF-κB and PKCβⅡwas examined in 143 cases of gastric carcinoma and normal gastric mucosa tissue with immunohistochemical technique.The datum were analyzed with χ2 tests.Results The expression rate of NF-κB in carcinoma tissues was 67.1%,which was significantly higher than that in normal tissues(21.6%,P0.05).The expression rate of PKCβ Ⅱ in carcinoma tissues was 58.4%,which was significantly higher than that in normal tissues(30.8%,P0.05).Both of them were positively related to the histological type,depth of tumor invasion and lymph node metastasis.Conclusions NF-κB and PKCβⅡ are overexpressed in gastric carcinoma and related to the histological type,depth of tumor invasion,lymph node and TNM stage.Both of them may cooperate with the development and progression of gastric carcinoma.Joint detection of the two types of indicators may play an important role in studying the development and progression,prognosis and targeted therapy of gastric carcinoma.