Research Advancement about Mechanism of Cerebral Edema After Hypertension Cerebral Hemorrhage

Intracerebral hemorrhage(ICH)is a specific subtype of stroke with high morbidity and mortality.Cerebral edema is the crucial factor of the second injury after hypertension cerebral hemorrhage.The formation of perihematoma edema begins at the early stage of ICH.Thrombin has been identified to play an important role in promoting perihematoma edema,thrombin inhibitors can reduce the edema formation.Red blood cell,hemoglobin,iron ion,platelet,leukocyte and cytokines are all related to the genesis of cerebral edema.Space-occupying lesions of hematoma and secondary ischemia around hematoma can promote the formation of cerebral edema.Matrix metalloproteinases(MMPs)are important markers of the complications and structure of ICH.