Mechanism and Influence Factor of Brain Edema Formation Caused by Primary Intracerebral Hemorrhage

Intracerebral haemorrhage (ICH) is a subtype of stroke with high morbidity and mortality.The deleterious effects of ICH may be divided into primary and secondary injury.Secondary injury(such as edema) may occur soon after ICH,as well as effects that occur up to 2 weeks later.The process of perihematoma edema formation starts the early ICH.Thrombin is located in the central role in promoting perihematoma edema has been documented,with evidence of reduced edema formation after administration of thrombin inhibitors.Otherwise,that play an important role in the complications and outcome of ICH are the matrix metalloproteinases(MMPs).