2012•Experimental and Laboratory MedicineRequires access

Changes and significance of immune function in nasopharyngeal carcinoma before and after radiotherapy

Zhou Mao-hua

Abstract

Objective To study the impact of radiotherapy on the immune function of patients with nasopharyngeal carcinoma.Methods A total of 134 cases of previously untreated patients with nasopharyngeal carcinoma were studied.Cellular immune phenotype(CD3+,CD4+ and CD4+/CD8+) changes were tested by flow cytometry and the immune function was compared before and after radiotherapy.Results Levels of CD3+,CD4+ and CD4+/CD8+ decreased significantly(P0.01) after radiation,while the level of CD8+ increased significantly.Conclusion Radiotherapy can weaken immune function and reduce the expression of CD4+/CD8+,suggesting that the immunotherapy should be supplemented during irradiation.

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Key concepts: Nasopharyngeal carcinoma, Immune system, Radiation therapy, CD8, Flow cytometry, CD3, Immunotherapy, Medicine