Clinical observation on early intravenous thrombolysis with urokinase in treatment of 25 patients with acute myocardial infarction

Objective To study the clinical efficacy and safety of early intravenous thrombolytic therapy with urokinase in treatment of patients with acute myocardial infarction.Methods Twenty five cases of AMI in observation group were treated with early application of intravenous thrombolytic therapy with urokinase for recanalization,and 25 cases of AMI in control group were treated with conventional therapy.The conditions of coronary recanalization in patients of these two groups were observed and compared.Results Rates of recanalization in coronary artery in patients of observation group and control group were 68% and 16% respectively,and the difference in recanalization rate between these two group was statistically significant(P0.05)between the two groups.The incidence of thrombolysis within 3 h reperfusion rate(81.8%) than thrombolysis group 3 ~ 6 h,6 ~ 12 h of thrombolytic recanalization rate(60.0%,25.0%),the difference was significant(P0.05).Conclusion Early thrombolytic therapy with urokinase is the key point for improving coronary artery recanalization rate of patients with acute myocardial infarction,thus it may reduce the mortality of patients with this disease.