Relationship betw een serum level of 25-hydroxyvitamin D and fasting blood glucose in healthy adults of Jinan

Objective To analyze the relationships among serum 25-hydroxy Vitamin D[25( OH) D] level,fasting blood glucose( FBG) and insulin sensitivity in the adults of Chinese Han population from Jinan. Methods A total of 1 244 subjects who lived in Jinan more than five years and aged between 20 to 82 years were included with random sampling method in this cross-sectional study. All individuals were divided into four groups based on the serum level of 25( OH) D:group A( ≤ 32. 1 nmol / L),group B( 32. 2-37. 7 nmol / L),group C( 37. 8-47. 4 nmol / L) and group D( ≥47. 5 nmol/L). Analysis of covariance was performed to compare serum FBG levels in the four groups. Simple and partial correlations and bivariate logistic regression analysis w ere used to explore the associations among FBG,insulin sensitivity and serum level of 25( OH) D. Results The estimated prevalence of impaired fasting glucose w as nearly 9. 24%. After adjustments for age and gender,FBG show ed a decrease w ith the increase of serum 25( OH) D level. After adjustments for the confounding factors such as age,gender,drinking status,body mass index,systolic blood pressure,high-density lipoprotein cholesterol and uric acid,serum 25( OH) D level show ed significant inverse correlation to FBG( r =- 0. 086,P = 0. 002) and significant positive correlation to log HOMA-β( r = 0. 079,P = 0. 005), w hereas no significant correlation w as found betw een log HOMA-IR and 25( OH) D. Bivariate Logistic regression analysis show ed that serum 25( OH) D level w as associated w ith impaired fasting glucose and Vitamine D may be a protective factor for FBG( OR = 0. 974,95% CI: 0. 955-0. 992,P = 0. 006). Conclusion Serum 25( OH) D level is closely related to FBG and the low 25( OH) D level may be a risk factor for impaired fasting glucose.