Changes and clinical significance of serum adiponectin and high sensitivity C-reactive protein in the children with Henoch-Schonlein purpura nephritis

Objective To explore the change and clinical significance of serum APN and hs-CRP in the children with Henoch-Schonlein purpura nephritis(HSPN).Methods The levels of serum APN and hs-CRP in 44 children with HSPN and 20 controls were measured by ELISA and immune nephelonretry.The correlation analysis of the levels of APN and hs-CRP in the children with HSPN were performed.Results The levels of serum APN in the acute and restoration period in the children with HSPN were lower than that of the control group(P0.01),the level of serum APN in the acute period group was lower than that of the restoration period group(P0.01).The levels of serum hs-CRP in the acute and restoration period in the children with HSPN were higher than that of the control group(P0.01),the level of serum hs-CRP in the acute period group was higher than that of the restoration period group(P0.01).The level of serum APN in the children with HSPN was negatively correlated with hs-CRP.Conclusion There was a mild inflammation reaction in restoration period in the children with HSPN;APN may be involved in the pathogenesis of HSPN,and plays important roles in the occurrence and development of HSPN.