Determination of Plasma Thrombomodulin Levels and Its Significance in Children with Henoch-Schonlein Purpura Nephritis

Objective To investigate the expression of thrombomodulin(TM) and its significance in children with Henoch-Schonlein purpura nephritis(HSPN).Methods The levels of plasma TM were measured by ELISA in 146 children with HSPN and 60 healthy children.The children with HSPN were divided into two groups:HSPN group(86 children with HSPN diagnosed by renal biopsy) and control group(60 children without renal lesions).Results Plasma TM levels in HSPN group,control group and healthy children group were(2.36±0.78)mg·L-1,(1.21±0.49)mg·L-1 and(0.56±0.63)mg·L-1,respectively,and there were obvious differences among the three groups(P0.05).In the classification of nephritis pathology,gradeⅠ,Ⅱ,Ⅲ and Ⅳ-Ⅵ were(1.53±0.68)mg·L-1,(1.95±0.67)mg·L-1,(2.76±1.13)mg·L-1 and(3.26±0.98)mg·L-1,respectively,and the differences were significant among the four grades(P0.05).Conclusion The levels of plasma TM significantly increase in children with HSPN.Moreover,the higher the plasma TM levels,the more serious the renal lesions.Therefore,the levels of plasma TM may be used as indexes to determine the occurrence of HSPN and the degree of renal lesions.