The expression of survivin mRNA in the peripheral blood of gastric cancer and its clinical significance

Background and purpose:Recently,pivotal studies have extensively investigated the role of the survivin gene in gastric cancers.This study aimed to investigate the clinical significance of the expression level of survivin mRNA in the peripheral blood of gastric cancers.Methods:The expression levels of survivin mRNA in the peripheral blood of gastric cancer and gastritis were detected by Real-time quantitative reverse transcription polymerase chain reaction(RT-PCR),while GAPDH was used as an internal reference gene.Results:Specimen from gastritis patients and gastric cancer patients indicated expression rates from survivin mRNA as 0%,and 86%.The expression of survivin mRNA showed no correlation with age,gender or lymph node metastasis(P0.05),but was significant different in the TNM stage(P0.05).The cox stepwise proportional hazards analysis showed that the expression levels of survivin mRNA remained significantly independent during prognosis.Conclusion:The expression levels of survivin mRNA was overexpressed in the peripheral blood of gastric cancer.These expression levels may also be an important marker for prognosis for gastric cancer patients.