The Preliminary Discuss of Reticulocyte Parameters in Large Cell Anemia Diagnosis

Objective To investigate the value of reticulocyte parameters applied in large cell anemia which are acute posthemorrhagic anemia,megaloblastic anemia(MgA),hemolytic anemia(HA),anemia for liver disease and myelodysplastic syndrome(MDS),in order to identify large cell anemia,and assist in clinical diagnosis.Methods Reticulocyte parameters were measured by Sysmex XE-5000 automatic blood cell analyzer in 70 acute posthemorrhagic anemia patients,42 HA patients,65 MgA patients,40 anemia for liver disease patients,28 MDS patients and 63 normal controls,and the differences were compared to normal controls.Results Compared with normal controls,reticulocyte percentage (Ret%) were remarkably increased in acute posthemorrhagic anemia group,hemolytic anemia group(HA),liver disease anemia group(P0.01).But in myelodysplastic syndrome group(MDS) it decreased significantly(P0.01),in megaloblastic anemia group(MA) there was no significant difference(P0.05).Immature reticulocyte indexs(IFR) increased significantly(P0.01) in all large cell anemia groups(P0.01).Compared with the control groups low fluorescent ratio(LFR) decreased in acute blood loss anemia,hemolytic anemia group(HA),megaloblastic anemia(MA) and myelodysplastic syndrome groups(MDS).In liver cell anemia group the middle fluorescent ratio(MFR) had no significant difference(P0.05).The other large cell anemia groups in the middle fluorescent ratio(MFR),all high fluorescent ratio(HFR) were significantly increased(P0.01).Conclusion Reticulocyte and parameters are sensitive index to reflex the function of bone marrow hematopoietic,reticulocyte and parameters play an important pole in large cell anemia diagnosis and differential diagnosis which have good application prospect.