Detection and clinical analyse of erythropoitin in patients with advanced cancer-related anemia

Objective To detect erythropoitin in patients with advanced cancer-related anemia and analyse the clinical signification.Methods Collect the blood of patients with advanced cancer-related anemia and erythropoitin was detected by radioimmuno-assay,hemoglobin and reticulocyte were detected also.Normal and patients with non-cancer-related anemia were employed as control groups.Results The erythropoitin of patients with advanced cancer-related anemia was 2.69±1.30 ug/L,hemoglobin 89.8±10.0 g/L,reticulocyte 2.78±1.06%.Erythropoitin was 1.59±0.69 ug/L,hemoglobin 136.1±11.3 g/L,reticulocyte 1.17±0.35% in normal controls.Erythropoitin was 2.82±1.16 ug/L,hemoglobin 90.2±11.5 g/L,reticulocyte 5.7±2.7% in controls of non-cancer-related anemia.Compared with normal controls,The erythropoitin,hemoglobin and reticulocyte of patients with advanced cancer-related anemia were significant difference(P0.01).The reticulocyte was significant different compared the patients with advanced cancer-related anemia with the patients with non-cancer-related anemia(P0.01).The coefficient of correlation between erythropoitin and reticulocyte was significant different in the patients with advanced cancer-related anemia compared with the patients with non-cancer-related anemia(P0.01).Conclusion The erythropoitin of patients with advanced cancer-related anemia was responsively increased but the reactivity of erythropoitin was weakened.