Clinical significance of reticulocyte-related parameters determination in anemic diseases

Objective To explore the clinical significance of reticulocyte(RET)-related parameters determination in anemia diagnosis.Methods Reticulocyte percentage(RET%),RET count(RET#),percent of high fluorescent reticulocyte(LFR%),percent of middle fluorescent reticulocyte(MFR%),percent of low fluorescent reticulocyte(HFR%),and immature RET fraction(IRF)of patients were determined by Sysmex XE-5000 automated blood analyzer and compared with the control group.Results LFR% of patients suffering from hemolytic anemia decreases,RET%,RET#,HFR%,MFR% and IRF of patients suffering hemolytic anemia were obviously higher than those of normal control group and the difference is quite significant(P0.01);while RET%,RET#,HFR%,MFR%,LFR%and IRF of patients with aplastic anemia were significantly reduced(P0.01);RET%,RET#,HFR%,MFR%,LFR%and IRF of patients suffering iron-deficiency anemia were slightly higher than those of normal control group,but there were no significant differences among them.Conclusion RET-related parameters are able to reflect the mature of reticulocyte more accurately,so it can evaluate the hematopoiesis of the bone marrow and it present an important value in the diagnosis and treatment of different types of anemia.