Mechanism and Effect of Telmisartan on Improving Insulin Resistance in OLETF Rats

Objective:To investigate the mechanism and effect of angiotensin II type 1(AT1) receptor blocker telmisar tan in OLETF rats with insulin resistance(IR).Methods:Forty-seven male OLETF rats were fed with high-fat diet for 14 weeks to establish the insulin resistance model,and rats were randomly assigned into five groups,IR model group,metformin(MET) group,the pioglitazone(P) group,the telmisartan(L) group and low-dose telmisartan(VL) group.Twelve LETO rats fed with normal diet served as the normal control(NC) group.The serum levels of fasting insulin(FINS),free fatty acids(FFA),omentin,retinol binding protein 4(RBP4),visfatin,plasma level of fasting blood glucose(FBG) and blood lipid were detected after 26 weeks treatment.The insulin resistance index(HOMA-IR) and insulin sensitivity index(ISI) were calculated.Re sults:Compared with group IR,the serum omentin and ISI were significantly higher in L group(P 0.01 or P 0.05),and the serum RBP4,visfatin,FBG,HOMA-IR,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C) and FFA were significantly decreased(P 0.01 or P 0.05).The multiple linear stepwise regression analysis showed that the serum omen tin and ISI were significant determinant of RBP4,and the serum omentin and HOMA-IR were significant determinant of visfa tin.Conclusion:Telmisartan can improve insulin resistance by inhibiting the expression of retinol binding protein 4 and vis fatin,enhancing the expression of omentin and regulating lipid leve1.