Effect observation of treated diabetic nephropathy by different doses irbesartan

Objective Treatment of different doses of irbesartan in diabetic nephropathy(DN) patient outcomes were compared.Methods Totally 56 patients with diabetic nephropathy were randomly divided into treatment group(300mg/d) and control group(150mg/d) each 28 cases,observed before and after 3 months of treatment blood pressure,blood creatinine(Scr),blood urea nitrogen(BUN),serum potassium(K) and urinary albumin changes.Results The patients had lower blood pressure after treatment,but the difference was not statistically significant(P0.05),urinary albumin were significantly decreased after treatment(P0.01),the treatment group decreased more significantly(P0.05).Conclusions Large dose of irbesartan(300mg/day) reduced urinary albumin is superior to low dose of irbesartan(150mg/day),independent of the DN patients have renal protective effects beyond blood pressure and good security.