Study on Synthesis Route of 2,4-Dichlorophenylbutanone

2,4-Dichlorophenylbutanone was synthesized with m-dichlorobenezene and n-butyryl chloride via Friedel-Crafts acylation reaction mechanism. The factors of reaction such as temperature of dropping, reaction temperature, reaction time and the ratio of the raw materials were discussed in detail. The optimum reaction condition was found. When the molar ratio of AlCl3:n-butyryl chloride was 1.3:1, n-butyryl chloride was added at 0-10℃, reaction temperature was 100-110℃ for 8h, the yield ratio of 2,4-dichlorophenylbutanone was improved from 38% to 65%.