Study on synthesis route of 2,4-dichlorophenyl ketone

2,4-Dichlorophenylpentanone was synthesized via Friedel-Crafts acylation reaction using m-dichlorobenezene and Valeryl chloride.The influence factors for reaction such as temperature of drop,reaction temperature,reaction time and the ratio of raw material were discussed in detail,The optimum reaction condition was found.When the ratio of AlCl3:Valeryl chloride=1.8:1 was used,Valeryl chloride was added at 0～10℃,reaction temperature was heated at 50～60℃ for 6hrs and then at 90～100℃ for 5 h,The yield of 2,4-Dichlorophenylpentanone was improved from 60% to 79%.