Survivin expression and its correlation with cell proliferation in colorectal cancer

Purpose:To study the expression of inhibitor apoptosis protein of Survivin in colorectal carcinoma and its correlation with clinicopathological feature and cell proliferation.Methods:Immunohistochemical staining of Survivin, Ki-67 and P53 was performed by the standard streptavidin-peroxidase (SP) technique for the paraffin sections of 106 colorectal cancers. The relationship between the Survivin expression and the proliferation index , P53 expression or the clinicopathological parameters was analyzed.Results:The proliferation index in Survivin-positive colorectal carcinoma (41.31%±(19.83%)) was significantly higher than in Survivin-negative colorectal carcinoma (26.21%±20.36%) (P0.05), positive correlation between survivin expression and proliferative activity of tumor cell measured by Ki-67 index was found.But there was no correlation between Survivin expression and P53.The positive rate of Survivin in colorectal carcinoma was (64.2%)(68/106), no expression of Survivin was detected in normal colorectal tissues. The positive rate of Survivin in middle to well differentiated colorectal carcinoma(72.4%)was significantly higher than that in poorly differentiated colorectal carcinoma(26.3%, P0.05). However, there was no correlation between Survivin expression and other clinicopathological parameters such as sex, tumor site, tumor depth, lymph node metastasis, distant metastasis, and Dukes’stage.Conclusions:The positive rate of inhibitor apoptosis protein of Survivin in colorectal carcinoma was 64.2%,it was significantly related to grade of histological differentiation of the colorectal carcinoma and may promote tumor cell proliferation.[