2011•Zhongguo fuyou baojianRequires access
Effects of irregular antibodies detection and antibody titers on neonatal hemolytic disease
Lou Bai
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Abstract
Objective:To detect the antibody titers of anti-A(B) and Rh blood types of pregnant women before delivery,explore the clinical significances of irregular antibodies detection and antibody titers of perinatal women before delivery.Methods:①In experimental group,475 pregnant women with incompatible blood type received IgG anti-A(B) antibody titer detection and Rh blood type antibody screening,the pregnant women with antibody titer≥64 received clinical intervention,the incidence,appearance time and degree of hemolysis among the infants were observed.②In control group,529 pregnant women with incompatible blood type who didn't receive irregular antibodies detection before delivery were selected randomly,the incidence,appearance time and degree of hemolysis among the infants were observed.Results:①In experimental group,6 cases were found with neonatal hemolysis,accounting for 1.26%,one case occurred within 24 hours,one case occurred within 48 hours,3 cases occurred within 72 hours and one case occurred after 72 hours;in control group;41 cases were found with neonatal hemolysis,accounting for 7.75%,5 cases occurred within 24 hours,21 cases occurred within 48 hours,12 cases occurred within 72 hours and 3 cases occurred after 72 hours,there was significant difference between the two groups(P0.05).②The average appearance times of neonatal jaundice in experimental group and control group were(63.56±17.67) hours and(44.39±26.95) hours,respectively.The average appearance time of neonatal jaundice in experimental group was latter than that in control group(P0.05).③The total bilirubin concentrations in serum of experimental group and control group were(165.30±20.10) μmol/L and(243.10±18.70) μmol/L,respectively.The degree of jaundice in control group was severer than that in experimental group(P0.05).Conclusion:Antibody titer detection among pregnant women before delivery can used as a screening index to predict the occurrence of neonatal hemolysis or not after birth,which has very important clinical significance.