The Significance of Prenatal Screening for Irregular Antibodies in the Prevention of Hemolytic Disease of Nerborn

Objective The purpose of prenatal detection of IgG anti-A/B antibody titers to explore prenatal screening for irregular antibodies in the prevention of hemolytic disease of newborn significance.Methods 317 cases of pregnant women detected for prenatal anti-A/B IgG antibody titer of couple's blood type incompatibility,and IgG anti-A/B titer ≥ 1:64 to administrate clinical interventions for pregnant women to observe the occurrence of post-natal baby hemolysis,hemolysin appears time and level;at the same time 317 cases of randomly selected couples blood group incompatibility,prenatal screening not done irregular maternal antibodies to investigate whether their infants hemolysis,hemolytic emerging time and extent.Results ①In the experimental group,13 cases of neonatal hemolytic occurred(4.10%),which occurred within 24 h was one case,48 h occurred in 3 cases,72 h occurs 3 cases,72 h were 6 cases occurred;control group,49 occurred in neonatal hemolytic cases(15.46%),which occurs within 24 h of 14 cases,48 h occurs 17 cases,72 h occurred in 15 cases,72 h were 3 cases occurred;two groups was statistically significance(P0.05).②In the experimental group,average time appearing of jaundice was(77.54±29.64)h;control group,(53.39±26.95)h,the experimental group is later than control group;③The degree of jaundice in the control group was severer than experimental group,two groups was statistically significance(P0.05).Conclusion ABO prenatal serum IgG anti-A/B antibody titer determination as to determine whether the fetus after birth occurred in hemolytic disease of newborn screening indicators.To reduce maternal and child neonatal ABO hemolytic disease of newborns caused by having a positive effect.