The value of multi-tumor markers protein chip diagnosis system in the differential diagnosis of benign and malignant pleural effusion and ascites

Aim To explore the reliability and validity of C12 system for the differential diagnosis of benign and malignant pleural effusion and ascites.Methods The levels of twelve tumor markers of pleural effusion and ascites were measured.Meanwhile,the diagnostic criteria were compared with the cytology of pleural effusion and ascites.Results The levels of CEA,Ferrtin,CA153 and CA125 of malignant pleural effusion group were remarkably higher than those of the benign group(P0.01).The levels of CEA,Ferrtin,CA199,CA242 and CA125 of malignant ascites group were remarkably higher than those of the benign group(P0.01).Different cancers always have different tumor markers.The coincident rate of C12 system was 83.78%,81.82% and 83.75% respectively when the result of cytology was positive,doubt and negative respectively.Conclusion Multi-Tumor Markers Protein Chip diagnosis System is helpful to the differential diagnosis of benign and malignant pleural effusion and ascites.Compared with the detection of single tumor marker,it can increase the diagnostic specificity of malignant pleural effusion and ascites.