Clinical study of premixed insulin analogues with high proportion combined with glimepirid on type 2 diabetic patients with poor glycemic control

【Objective】To investigate clinical effects and safety of premixed insulin analogues with high proportion combined with glimepirid on type 2 diabetic patients with poor glycemic control. 【Methods】300 patients with type 2 diabetic patients with poor glycemic control were chosen and randomly divided into two groups including control group(150 patients) with glimepirid orally treatment in the morning combined with insulin glarsin subctaneous injection treatment at bedtime and observation group(150 patients) with premixed insulin analogues with high proportion(novomix 50) orally treatment in the morning combined with insulin glarsin subctaneous injection treatment at bedtime; and the total compliance rate of blood glucose control, fasting blood glucose(FBG) and 2-hour postprandial blood glucose(2hPBG), HbA1 c, triglycerides(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), the compliance time of blood glucose, the incidence, body weight increasing amount and insulin dosage of hypoglycemia of both groups were compared. 【Results】The total compliance rate of blood glucose control of observation group was significant better than control group [93.33% vs 84.67%,P 0.05]. The biochemical indexes of both groups after treatment was significant better than before treatment including FBG, 2hFBG, HbA1 c, TG, TC and LDL-C(P 0.05). The improving degree of biochemical indexes of observation group after treatment was significant better than control group including FBG, 2hFBG and HbA1c(P 0.05).There was no significantly difference in HDL-C between 2 groups before and after treatment(P 0.05). The compliance time of blood glucose, the incidence of hypoglycemia, body weight increasing amount and insulin dosage of observation treatment group was significant better than control group [(10.07±2.24) vs(13.32±3.10) d, 2.67% vs 12.67%,(18.29±4.54) vs(30.10±4.68) u, P 0.05].【Conclusion】Premixed insulin analogues with high proportion combined with glimepirid on type 2 diabetic patients with poor glycemic control can efficiently improve control effect of blood glucose and biochemical indexes, and reduce the risk of hypoglycemia.