Association between connexin37 rs1764390 gene polymorphisms and ischemic stroke in Chinese Han population

AIM:To investigate the association between connexin37 rsl764390 gene polymorphisms and the susceptibility of IS in Chinese Han population.METHODS:A case-control study consisted of184 IS patients and 149 healthy controls of Han nationality recruited from Hunan province was carried out.All the subjects were genotyped by polymerase chain reaction-estriction fragment length polymorphism(PCR-RFLP).RESULTS:The genotype frequencies of AA,AG,GG in patients group were30.44%,48.91%,20.65%,respectively,and the frequency of allele G was 45.11%.In control group,the genotype frequencies of AA,AG,GG were 24.16%,51.01%,24.83%,respectively,and the frequency of allele G was 50.34%.There were no significant differences between IS patients and controls in genotype frequencies of AA,AG,GG and allele frequencies of A and G(χ~2=1.88 and 1.80,both P 0.05).CONCLUSION:No association was found between rsl764390 polymorphism in Cx37 gene and the risk of IS in this study.Cx37 rsl764390(A/G) may not be a genetic marker for IS susceptibility in Chinese Han population.