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1995•Chinese Journal of Clinical PharmacyRequires access

PHARMACOKINETICS OF FOUR KINDS OF OFLOXACIN TABLETS IN HUMAN BODY

Shen Yun-yu, Xia Yun-yue

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Abstract

Pharmacokinetics parameters of four kinds of ofloxacin tablets were studied in 10 healthy young male volunteers. The concentration-time curve after a single oral dose of ofloxacin was shown by two-compartment open model. Tm and Cmax obtained from our studies showed no significant difference. AUC of four kinds of ofloxacin tablets were 38. 84 ±3. 26 (B), 28. 90±3. 85 (S) (J) and 36. 73±7. 54mg · h-1 · L-1 (D) respectively. There was difference among them . The relative bioavailabilities of S. J and D to B were 74. 41%, 93.98%, 94. 57% respectively

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What this paper is about

Pharmacokinetics parameters of four kinds of ofloxacin tablets were studied in 10 healthy young male volunteers. The concentration-time curve after a single oral dose of ofloxacin was shown by two-compartment open model. Tm and Cmax obtained from our studies showed no significant difference. AUC of four kinds of ofloxacin tablets were 38. 84 ±3. 26 (B), 28. 90±3. 85 (S) (J) and 36. 73±7. 54mg · h-1 · L-1 (D) respectively. There was difference among them . The relative bioavailabilities of S. J and D to B were 74. 41%, 93.98%, 94. 57% respectively

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Available abstract

Pharmacokinetics parameters of four kinds of ofloxacin tablets were studied in 10 healthy young male volunteers. The concentration-time curve after a single oral dose of ofloxacin was shown by two-compartment open model. Tm and Cmax obtained from our studies showed no significant difference. AUC of four kinds of ofloxacin tablets were 38. 84 ±3. 26 (B), 28. 90±3. 85 (S) (J) and 36. 73±7. 54mg · h-1 · L-1 (D) respectively. There was difference among them . The relative bioavailabilities of S. J and D to B were 74. 41%, 93.98%, 94. 57% respectively

Key concepts: Ofloxacin, Pharmacokinetics, Cmax, Pharmacology, Significant difference, Medicine, Chemistry, Internal medicine

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