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2002•Journal of Jiangsu Clinical MedicineRequires access

STUDY ON THE PHARMACOKINETICS AN RELATIVE BIOAVAILABILITIES OF OFLOXACINS IN HEALTH VOLUNTEERS

Chen Tie-sha

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Abstract

Objective:Compared with ofloxacin tablets,to study the pharmacokineties and relative bioavailabilities of ofloxacin capsules.Methods:10 male health volunteers orally took a single does of 300mg ofloxacins in randomized selfcrossover way.ofloxacin concetration was determined by high performance liquid chromatography.Data of serum level-time were disposed with PKBP-N1 of software and computer.Results:The concentration time data of ofloxacin was fitted to two compartment model and the main pharmacokinetic parameters are as following sapsule:C max =(5.22±0.87)ug/ml;T max =(0.96±0.04)h;AUC 0-24 =(33.46±3.92)μg/(ml·h);t 1/2 (β)=6.02±0.40)h.Tablet:C max (5.09±0.77)μg/ml;T max =(0.89±0.21)h;AUC 0-24 =(31.46±2.8)μg/ml·h;t 1/2 (β)=(6.12±0.39)h.Relative:Bioavaiability of capsule was (106.23±5.63).Compared with tablet.Conclusion:The two formulations are of bioequivaicnce.

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Objective:Compared with ofloxacin tablets,to study the pharmacokineties and relative bioavailabilities of ofloxacin capsules.Methods:10 male health volunteers orally took a single does of 300mg ofloxacins in randomized selfcrossover way.ofloxacin concetration was determined by high performance liquid chromatography.Data of serum level-time were disposed with PKBP-N1 of software and computer.Results:The concentration time data of ofloxacin was fitted to two compartment model and the main pharmacokinetic parameters are as following sapsule:C max =(5.22±0.87)ug/ml;T max =(0.96±0.04)h;AUC 0-24 =(33.46±3.92)μg/(ml·h);t 1/2 (β)=6.02±0.40)h.Tablet:C max (5.09±0.77)μg/ml;T max =(0.89±0.21)h;AUC 0-24 =(31.46±2.8)μg/ml·h;t 1/2 (β)=(6.12±0.39)h.Relative:Bioavaiability of capsule was (106.23±5.63).Compared with tablet.Conclusion:The two formulations are of bioequivaicnce.

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Available abstract

Objective:Compared with ofloxacin tablets,to study the pharmacokineties and relative bioavailabilities of ofloxacin capsules.Methods:10 male health volunteers orally took a single does of 300mg ofloxacins in randomized selfcrossover way.ofloxacin concetration was determined by high performance liquid chromatography.Data of serum level-time were disposed with PKBP-N1 of software and computer.Results:The concentration time data of ofloxacin was fitted to two compartment model and the main pharmacokinetic parameters are as following sapsule:C max =(5.22±0.87)ug/ml;T max =(0.96±0.04)h;AUC 0-24 =(33.46±3.92)μg/(ml·h);t 1/2 (β)=6.02±0.40)h.Tablet:C max (5.09±0.77)μg/ml;T max =(0.89±0.21)h;AUC 0-24 =(31.46±2.8)μg/ml·h;t 1/2 (β)=(6.12±0.39)h.Relative:Bioavaiability of capsule was (106.23±5.63).Compared with tablet.Conclusion:The two formulations are of bioequivaicnce.

Key concepts: Ofloxacin, Pharmacokinetics, Medicine, Capsule, Bioavailability, Pharmacology, Chromatography, Chemistry

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