Dynamic changes and clinical significance of neuron-specific enolase and myelin base protein in serum of hypoxic ischemic encephalopathy

Objective To investigate the changes of serum neuron specific enolase(NSE) and myelin base protein(MBP) in neonates with hypoxic ischemic encephalopathy(HIE).Methods Forty newborns with HIE were assigned into three groups,mild HIE group(n=10),moderate HIE group(n=16) and severe HIE group(n=14).Ten normal newborns selected as control group.Radio immunoassay measured serm levels of NSE.Serum levels of MBP assayed by ELISA analyzer.Results ① Blood NSE levels in all objective cases were significantly higher than those in the control cases at 1 d after HIE and 3 d after therapy(P0.05).Blood NSE levels in severity degree and moderate degree cases were significantly higher than those in the control cases at 7-10 d after therapy(P0.05),but the NSE levels recovered to normal in slight degree cases.② The serum MBP level in severe group increased obviously during the acute stage(P0.01).There was no significant difference between control group and mild HIE group(P0.05).There was significant difference between the control group and severe group(P0.01).Conclusion The levels of NSE in cord blood are the symbol reflecting the early brain damage.The determination of blood MBP levels can be used to evaluate the degree of brain injury of HIE patient.