The Influence of Antineoplastic Polypeptide from Buthus Martensii Venom on Tumor Weight and Hematological System of Hepatoma-bearing Mice After Radiotherapy

Objective To observe the effect of antineoplastic polypeptide from Buthus martensii venom (APBMV) combined with radiotherapy on tumor weight and hematological system of Hepatoma 22 bearing mice.Methods One hundred H 22 bearing mice were used in this experiment.The tumor growth inhibiting rate (IR%),WBC count,spleen index (SI) and hemoglobin were used as the parameters.After radiotherapy (RT) or after administration of different dosage of APBMV combined with RT,the changes of these parameters were observed.Results On the 6th day and 9th after radiotherapy,the tumor weights decreased after administrating APBMV combined with RT,in which IR were 78 28% and 70 45%,respectively (comparing with RT and APBMV group, P 0 05 or P 0 01).In RT+APBMV group,WBC count and SI were also higher than those of the RT group ( P 0 05).The results of hemoglobin content in peripheral blood indicated that there were no differences among all groups ( P 0 05).Conclusions The inhibiting effect of the combining therapy (APBMV combining with RT) on H 22 was stronger than radiation or APBMV alone.APBMV can decrease the hematological system injury induced by radiation in some extent.