Clinical observation of simvastatin combined with nimodipine in treatment of subarachnoid hemorrhage

Objective To explore the therapeutic effect of simvastatin combined with nimodipine in the treatment of subarachnoid hemorrhage (SAH). Methods Ninety-six patients with SAH were randomly divided into the treatment group and the control group. Patients in the control group were treated with routine therapy, and patients in the treatment group were given simvastatin combined with nimodipine on the basis of routine therapy. The scores of neurological impairment, the incidence of cerebral vasospasm, the incidence of hydrocephalus, the incidence of rebleeding and mortality rate between the two groups were compared. Results Neurological impairment scores, the incidence of cerebral vasospasm, the incidence of hydrocephalus and mortality rate in the treatment group were significantly lower than those in control group ( P 0. 05 ) , but the incidence of rebleeding showed no statisical significance between two groups ( P 0. 05 ). Conclusion Simvastatin combined with nimodipine can evidently improve the neurological function in patients with SAH, and reduce the incidence of cerebrel vasospasm, and hydrocephalus, and mortality rate after SAH.