Therapeutic effect of simvastatin on subarachnoid hemorrhage

Objective To explore the therapeutic effect of simvastatin on subarachnoid hemorrhage(SAH).Methods Totally 128 SAH patients,who were admitted to our hospital from March 2003 to March 2005,were randomly divided into 2 groups:simvastatin group(n=64)which were treated with routine therapy,intravenous injection of nimodipine and oral or nasal feed of 20 mg simvastatin,twice a day;control group(n=64)which were treated with routine therapy,intravenous injection of nimodipine and oral taking of placebo instead of simvastatin,twice a day.Two weeks later all patients were given neurologic impairment score and head CT.Results Neurologic impairment scores in simvastatin group were significantly lower than those of control group(P0.05).The rate of cerebral vasospasm(CVS)is 6.25%(4/64)in simvastatin group and 17.19%(11/64)in control group,showing significant difference between the two(P0.01).Conclusion Simvastatin can evidently improve the neurological function and the therapeutic outcomes after SAH.